DENKI (Dual ENKephalinase Inhibitors), a new class of painkillers devoid of abuse potential and of opiate side-effects
Published on June 11, 2018
Published on June 11, 2018
Substituted α-mercaptoketones, new types of specific neprilysin inhibitors Abstract New neprilysin inhibitors containing an α-mercaptoketone HSC(R1R2)CO group, as zinc ligand were designed. Two parameters were explored for potency optimization: the size of the inhibitor which could interact with the S1, S1′ or S2′ domain of the enzyme and the nature of the substituents R1, R2 of […] Read full post »
Published on August 7, 2017
Published on May 19, 2017
