Publications

DENKI (Dual ENKephalinase Inhibitors), a new class of painkillers devoid of abuse potential and of opiate side-effects

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors Abstract New neprilysin inhibitors containing an α-mercaptoketone HSC(R1R2)CO group, as zinc ligand were designed. Two parameters were explored for potency optimization: the size of the inhibitor which could interact with the S1, S1′ or S2′ domain of the enzyme and the nature of the substituents R1, R2 of […] Read full post »

Dual enkephalinase inhibitor (DENKI) PL265: a novel topical treatment for ocular pain ?

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