Publications

PHARMALEADS PRESENTS NEW PUBLICATION IN PAIN IN COLLABORATION WITH “INSTITUT DE LA VISION” IN PARIS, ABOUT THE PHARMACOLOGICAL EFFECTS OF TOPICAL ADMINISTRATION OF PL265 ON OCULAR PAIN

Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment. To date, the management of chronic ocular pain remains a therapeutic challenge in ophthalmology. The main endogenous opioids (enkephalins) play a key role in pain control but exhibit only transient analgesic effects due to their rapid degradation. The aim of […] Read full post »

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors Abstract New neprilysin inhibitors containing an α-mercaptoketone HSC(R1R2)CO group, as zinc ligand were designed. Two parameters were explored for potency optimization: the size of the inhibitor which could interact with the S1, S1′ or S2′ domain of the enzyme and the nature of the substituents R1, R2 of […] Read full post »

Dual enkephalinase inhibitor (DENKI) PL265: a novel topical treatment for ocular pain ?

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