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The exceptional strength of the botulinum toxin comes from its inhibitory capability that blocks the cholinergic transmission and therefore leads to the halt of the vital functions.
Botulinum Toxin as a Biological Weapon
Copyright JAMA. 2001;285:1059-1070
Toxins B,C,D and F are degrading the synaptobrevin, when toxins A and E are degrading the SNAP25, two key molecules belonging to the SNARE complex system involved in the fusion of the acetylcholine-contained vesicle membrane and neuronal cell membrane.
Botulinum Toxin as a Biological Weapon
Copyright JAMA. 2001;285:1059-1070
By preventing the vesicle from being bound to the membrane, botulinum toxins block the release of acetylcholine. This leads to flaccid muscles paralysis and nerves destruction. Then people show difficulties in breathing and swallowing, leading to death.
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